A Novel Oncolytic Virotherapy Using Live-attenuated Poliovirus for Soft Tissue Sarcoma
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چکیده
INTRODUCTION: The poliovirus is a nonenveloped plus-strand RNA virus belonging to Picornaviridae, and is the causative pathogen of paralytic poliomyelitis. The selective targeting of motor neurons by poliovirus is most likely determined by the distribution of its cellular receptor, the Ig superfamily molecule CD155 (also known as poliovirus receptor: PVR). Recently, a number of reports have indicated that the poliovirus induces cell death in some types of cancer originating from the neural crest, including malignant glioma [1] and neuroblastoma [2]. We herein investigated whether a soft tissue sarcoma cell line, HT1080, shows upregulated expression of CD155. We also examined whether live-attenuated polioviruses have oncolytic effects on soft tissue sarcomas in vitro and in vivo.
منابع مشابه
Oncolytic virotherapy for human bone and soft tissue sarcomas using live attenuated poliovirus.
The poliovirus receptor CD155, is essential for poliovirus to infect and induce death in neural cells. Recently, CD155 has been shown to be selectively expressed on certain types of tumor cells originating from the neural crest, including malignant glioma and neuroblastoma. However, the expression pattern of CD155 in soft tissue sarcoma has not be...
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